{"id":1678,"date":"2025-01-17T01:38:37","date_gmt":"2025-01-17T01:38:37","guid":{"rendered":"https:\/\/santerim.info\/fr\/?p=1678"},"modified":"2025-01-17T01:38:38","modified_gmt":"2025-01-17T01:38:38","slug":"loms-valide-un-test-cle-pour-un-traitement-securise-du-paludisme-a-p-vivax","status":"publish","type":"post","link":"https:\/\/santerim.info\/fr\/loms-valide-un-test-cle-pour-un-traitement-securise-du-paludisme-a-p-vivax\/","title":{"rendered":"L\u2019OMS valide un test cl\u00e9 pour un traitement s\u00e9curis\u00e9 du paludisme \u00e0 P. vivax"},"content":{"rendered":"\n

Le 18 d\u00e9cembre 2024, l\u2019Organisation mondiale de la Sant\u00e9 (OMS) a pr\u00e9qualifi\u00e9 le premier test de diagnostic de la carence en glucose-6-phosphate d\u00e9shydrog\u00e9nase (G6PD), qui peut aider \u00e0 administrer en toute s\u00e9curit\u00e9 les traitements recommand\u00e9s par l\u2019OMS pour pr\u00e9venir les rechutes du paludisme \u00e0 Plasmodium vivax<\/em> (P. vivax<\/em>).<\/p>\n\n\n\n

La pr\u00e9qualification de ce test de diagnostic de la carence en G6PD marque une \u00e9tape importante en vue de faciliter l\u2019administration d\u2019un traitement s\u00fbr et efficace du paludisme \u00e0 P. vivax<\/em>. L\u2019OMS r\u00e9affirme ainsi qu\u2019elle s\u2019engage \u00e0 garantir un acc\u00e8s \u00e9quitable \u00e0 des moyens m\u00e9dicaux vitaux \u00e0 l\u2019\u00e9chelle mondiale. Quelque 500 000 personnes, pour la plupart des enfants, meurent du paludisme chaque ann\u00e9e.<\/p>\n\n\n\n

La pr\u00e9qualification de ce test intervient imm\u00e9diatement apr\u00e8s la pr\u00e9qualification, d\u00e9but d\u00e9cembre, de deux nouveaux produits \u00e0 base de taf\u00e9noquine<\/a> (en anglais) destin\u00e9s \u00e0 \u00e9viter les rechutes du paludisme \u00e0 P. vivax<\/em>, et ces traitements ont \u00e9t\u00e9 recommand\u00e9s dans les lignes directrices de l\u2019OMS sur le paludisme<\/a> actualis\u00e9es publi\u00e9es fin novembre.<\/p>\n\n\n\n

Cet ensemble d\u2019actions de l\u2019OMS s\u2019inscrit dans le cadre de l\u2019adoption r\u00e9cente par l\u2019Organisation de processus synchronis\u00e9s et parall\u00e8les pour deux fonctions cl\u00e9s : l\u2019\u00e9laboration de recommandations pour les produits de sant\u00e9 essentiels et la supervision de leur pr\u00e9qualification.<\/p>\n\n\n\n

Bien que ces processus restent enti\u00e8rement ind\u00e9pendants, leur harmonisation vise \u00e0 raccourcir consid\u00e9rablement les d\u00e9lais n\u00e9cessaires pour acheminer des produits de sant\u00e9 vitaux dans les pays \u00e0 revenu faible ou interm\u00e9diaire inf\u00e9rieur. Cette rationalisation montre bien que l\u2019OMS tient \u00e0 am\u00e9liorer l\u2019\u00e9quit\u00e9 en mati\u00e8re de sant\u00e9 dans le monde en permettant un acc\u00e8s plus rapide aux produits vitaux.<\/p>\n\n\n\n

Le paludisme \u00e0 P. vivax<\/em> est end\u00e9mique dans toutes les R\u00e9gions de l\u2019OMS, \u00e0 l\u2019exception de la R\u00e9gion europ\u00e9enne, et il a \u00e9t\u00e9 \u00e0 l\u2019origine d\u2019environ 9,2 millions de cas cliniques en 2023. P. vivax<\/em> est l\u2019esp\u00e8ce dominante dans la plupart des pays en dehors de l\u2019Afrique subsaharienne.<\/p>\n\n\n\n

La carence en G6PD est une maladie g\u00e9n\u00e9tique qui touche plus de 500 millions de personnes. Alors que la plupart des personnes ignorent qu\u2019elles ont une carence en G6PD et n\u2019en ressentent jamais les effets, certains m\u00e9dicaments administr\u00e9s pour pr\u00e9venir la rechute du paludisme \u00e0 P. vivax<\/em> peuvent entra\u00eener une h\u00e9molyse (destruction des globules rouges) aigu\u00eb. Sans test accessible et fiable pour d\u00e9tecter la carence en G6PD, il est difficile de fournir en toute s\u00e9curit\u00e9 des traitements pour \u00e9viter les rechutes, ce qui limite l\u2019utilisation g\u00e9n\u00e9ralis\u00e9e de cette th\u00e9rapie efficace.<\/p>\n\n\n\n

\u00ab La pr\u00e9qualification de ce test enzymatique pour d\u00e9tecter la carence en G6PD chez les personnes atteintes de paludisme \u00e0 P. vivax<\/em> peut aider les pays \u00e0 am\u00e9liorer l\u2019acc\u00e8s aux tests de qualit\u00e9 dont ils ont tant besoin et ainsi de pr\u00e9venir et de traiter ce type de paludisme r\u00e9current de mani\u00e8re s\u00fbre et efficace \u00bb, a d\u00e9clar\u00e9 la Dre<\/sup> Yukiko Nakatani, Sous-Directrice g\u00e9n\u00e9rale de l\u2019OMS charg\u00e9e de l\u2019acc\u00e8s aux m\u00e9dicaments et aux produits de sant\u00e9. \u00ab Nous n\u2019avons pas encore re\u00e7u d\u2019autres demandes de pr\u00e9qualification pour ce type de tests. Nous souhaitons que davantage de produits nous soient soumis afin d\u2019\u00e9largir la gamme d\u2019outils de diagnostic efficaces disponibles pour les pays qui en ont besoin \u00bb, a-t-elle ajout\u00e9.<\/p>\n\n\n\n

\u00ab Une meilleure disponibilit\u00e9 du test peut contribuer \u00e0 renforcer la lutte mondiale contre le paludisme en faisant baisser le nombre d\u2019infections \u00e0 P. vivax<\/em> dues \u00e0 une rechute et ainsi la transmission ult\u00e9rieure \u00bb, a d\u00e9clar\u00e9 le Dr<\/sup> Daniel Ngamije Madandi, Directeur du Programme mondial de lutte contre le paludisme de l\u2019OMS.<\/p>\n\n\n\n

Les dispositifs de test qui permettent de distinguer avec pr\u00e9cision les personnes pr\u00e9sentant des niveaux de G6PD sup\u00e9rieurs \u00e0 la normale de celles dont les niveaux sont inf\u00e9rieurs donnent des informations essentielles aux cliniciennes et aux cliniciens pour d\u00e9cider quel sch\u00e9ma th\u00e9rapeutique est le plus appropri\u00e9 afin d\u2019\u00e9viter les rechutes du paludisme \u00e0 P. vivax<\/em>, y compris la primaquine \u00e0 faible ou \u00e0 forte dose et la taf\u00e9noquine en dose unique.<\/p>\n\n\n\n

L\u2019outil de diagnostic STANDARD G6PD System, fabriqu\u00e9 par SD Biosensor, Inc., est une solution semi-quantitative utilisable au plus pr\u00e8s des patientes et des patients et con\u00e7ue pour mesurer l\u2019activit\u00e9 enzymatique du G6PD dans le sang total capillaire ou veineux. Le dispositif est destin\u00e9 \u00e0 \u00eatre utilis\u00e9 \u00e0 la fois en laboratoire et en dehors et fonctionne avec l\u2019analyseur STANDARD G6PD, un appareil portable, qui fournit des r\u00e9sultats en quelques minutes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Le 18 d\u00e9cembre 2024, l\u2019Organisation mondiale de la Sant\u00e9 (OMS) a pr\u00e9qualifi\u00e9 le premier test de diagnostic de la carence en glucose-6-phosphate d\u00e9shydrog\u00e9nase (G6PD), qui peut aider \u00e0 administrer en toute s\u00e9curit\u00e9 les traitements recommand\u00e9s par l\u2019OMS pour pr\u00e9venir les rechutes du paludisme \u00e0 Plasmodium vivax (P. vivax). La pr\u00e9qualification de ce test de diagnostic de la carence en<\/p>\n","protected":false},"author":3,"featured_media":1679,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":{"0":"post-1678","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-3"},"yoast_head":"\nL\u2019OMS valide un test cl\u00e9 pour un traitement s\u00e9curis\u00e9 du paludisme \u00e0 P. vivax - Sante rim<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/santerim.info\/fr\/loms-valide-un-test-cle-pour-un-traitement-securise-du-paludisme-a-p-vivax\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019OMS valide un test cl\u00e9 pour un traitement s\u00e9curis\u00e9 du paludisme \u00e0 P. vivax - Sante rim\" \/>\n<meta property=\"og:description\" content=\"Le 18 d\u00e9cembre 2024, l\u2019Organisation mondiale de la Sant\u00e9 (OMS) a pr\u00e9qualifi\u00e9 le premier test de diagnostic de la carence en glucose-6-phosphate d\u00e9shydrog\u00e9nase (G6PD), qui peut aider \u00e0 administrer en toute s\u00e9curit\u00e9 les traitements recommand\u00e9s par l\u2019OMS pour pr\u00e9venir les rechutes du paludisme \u00e0 Plasmodium vivax (P. vivax). 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